Metabolites of 1,2,3,4-tetrachlorobenzene in monkey urine

Journal Article · Tue Jan 01 04:00:00 UTC 1985 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398509530689· OSTI ID:6380200

Schwartz, H; Chu, I; Villeneuve, D C; Viau, A; Benoit, F M

(/sup 14/C(U))-Labeled 1,2,3,4-tetrachlorobenzene was administered orally to squirrel monkeys. Urine was collected from these animals, pooled and analyzed for metabolites by thin-layer chromatography, high-performance liquid chromatography, and gas chromatography-mass spectroscopy. N-Acetyl-s(2,3,4,5-tetrachlorophenyl) cysteine was shown to be the major metabolite and accounted for 85% of the radioactivity found in urine. A minor metabolite was identified at 2,3,4,5-tetrachlorophenol. This study demonstrates for the first time that an N-acetyl cysteine conjugate has been isolated and identified as metabolite of a chlorinated benzene. This pattern of chlorobenzene metabolism is significantly different from the one obtained with the rat and rabbit, where tetrachlorophenols constitute the major metabolites.

• Research Organization: Environmental Health Directorate, Ottawa, Ontario
• OSTI ID: 6380200
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 15:5; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BIOLOGICAL VARIABILITY
BIOLOGICAL WASTES
BODY FLUIDS
CARBON 14 COMPOUNDS
CHLORINATED AROMATIC HYDROCARBONS
CHROMATOGRAPHY
HALOGENATED AROMATIC HYDROCARBONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MASS SPECTROSCOPY
MATERIALS
METABOLISM
METABOLITES
MONKEYS
ORAL ADMINISTRATION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PRIMATES
SEPARATION PROCESSES
SPECTROSCOPY
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES