I-131 labelled peanut lectin renal kinetics in cis-platin induced tubular toxicity in dogs

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6759444

Boniface, G R; Willans, D J; Noujaim, A A

Quantitative I-131 labelled Peanut lectin (I-131-PNA) renal clearance was determined in dogs before and after a 5 day single cycle cis-platinum chemotherapy regimen (0.5mg/Kg/day). Results were statistically compared with E.R.P.F. (I-131-Hippuran), G.F.R. (Tc-99m-DTPA), and serum biochemistry and correlated with histopathology. I-131-PNA clearance was significantly reduced in all dogs 5 days after cessation of cis-platinum treatment (mean ..delta..S% = 71.3%) and similar reductions in the gamma camera derived renogram peak were demonstrated (mean ..delta..S% = 65.8%). E.R.P.F. was noted to drop by a minor degree (mean ..delta..S% = 20.9%) post treatment. G.F.R. was diminished (mean ..delta..S% = 46.6%) and serum creatinine elevated (mean ..delta..S% = 42.7%) in all dogs compared to their pretreatment values. Histopathology demonstrated variable degrees of tubular toxicity ranging from mild to severe. The degree of change of the I-131-PNA values was significantly greater than that predicted by indicators of glomerular function. These results suggest that quantitative renal tubular imaging may be useful in the determination of tubular toxicity.

• Research Organization: Univ. of Alberta and Edmonton General Hospital, Edmonton, Alberta
• OSTI ID: 6759444
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOMEDICAL RADIOGRAPHY
BLOOD SERUM
BODY
CAMERAS
CHEMISTRY
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
COMPLEXES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DOGS
DYNAMIC FUNCTION STUDIES
ELEMENTS
ENZYME INHIBITORS
GLOMERULI
HISTOLOGY
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LECTINS
MAMMALS
MEDICINE
METALS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGY
PEANUTS
PLATINUM
PLATINUM COMPLEXES
PLATINUM METALS
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIONUCLIDE KINETICS
RENOGRAPHY
SEEDS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
TOXICITY
TRACER TECHNIQUES
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
TUBULES
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES