/sup 99m/Tc-DTPA renal studies for acute tubular necrosis: specificity of dissociation between perfusion and clearance

Journal Article · Sun Feb 01 04:00:00 EST 1981 · Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.136.2.249· OSTI ID:6643814

Shanahan, W S.M. ^[1]; Klingensmith, III, W C; Weil, R III

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1. Univ. Hospital, Denver, CO

In order to evaluate the usefulness of radionuclide renal studies in differentiating acute tubular necrosis from causes of decreased renal clearance (e.g., rejection) in renal transplant patients, we assumed that acute tubular necrosis would be common during the first 4 days after cadaveric transplantation (group 1) and uncommon 3 weeks or longer after transplantation (group 2). There were 38 renal studies in 34 patients in group 1 and 62 studies in 27 patients in group 2. Each renal study consisted of both a technetium-99m-DTPA and an iodine-131 hippuran study. Perfusion, clearance, and transit time in the /sup 99m/Tc-DTPA study, and clearance and transit time in the /sup 131/I-hippuran study were visually graded on a 5 point scale without knowledge of the time of study of clinical diagnosis. There were 19 studies in group 1 and 25 studies in group 2 with clearance decreased two or more gradations. Eleven /sup 99m/Tc-DTPA studies had perfusion 2 or more gradations better than clearance; all 11 were in group 1 (p < 0.01). Other dissociations within the /sup 99m/TcDTPA and /sup 131/I-hippuran studies, or between them, did not distinguish the two groups. Data support the hypothesis that decreased clearance with relatively well preserved perfusion in /sup 99m/Tc-DTPA studies is common in acute tubular necrosis and uncommon in other causes of decreased renal clearance.

• OSTI ID: 6643814
• Journal Information: Am. J. Roentgenol.; (United States), Journal Name: Am. J. Roentgenol.; (United States) Vol. 136:2; ISSN AJROA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COMPARATIVE EVALUATIONS
CONTRAST MEDIA
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DRUGS
DTPA
EXCRETION
HIPPURAN
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
NECROSIS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PERFUSED ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RENAL CLEARANCE
RESPONSE MODIFYING FACTORS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIME DEPENDENCE
TRANSPLANTS
TUBULES
USES
YEARS LIVING RADIOISOTOPES