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Metallothaionein in the extracellular fluids as an index of cadmium toxicity

Journal Article · · Environ. Health Perspect.; (United States)
DOI:https://doi.org/10.1289/ehp.7928267· OSTI ID:6758542
;
In rats injected with CdCl2 5 days/week, metallothionein was detected in plasma by gel filtration chromatography as early as four weeks. Signs of renal toxicity were evident from gluocosuria and proteinuria. The excretion of cadmium in urine at this time was rather low. The amount of metallothionein in plasma, as determined by /sup 109/Cd-binding to the 10,000 molecular weight fraction, increased markedly during week 14. Signs of renal toxicity were were evident from glucosuria and proteinuria. The excretion of cadmium in urine increased markedly and the majority of it was in the form of metallothionein. It is suggested that the appearance of metallothionein in plasma and urine can be used as specific indices of cadmium poisoning and that the assay of the protein in these fluids may be useful in screening for excessive cadmium exposure.
Research Organization:
Univ. of Rochester, NY
OSTI ID:
6758542
Journal Information:
Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 28; ISSN EVHPA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CADMIUM 109
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CADMIUM ISOTOPES
CHLORIDES
CHLORINE COMPOUNDS
DIAGNOSIS
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
TOXICITY
TRACER TECHNIQUES
URINE
UROGENITAL SYSTEM DISEASES
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES