Biologic indicators of cadmium nephrotoxicity in persons with low-level cadmium exposure

Journal Article · Thu Mar 01 04:00:00 EST 1984 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8454163· OSTI ID:5761775

Nogawa, K

The relationship between abnormal urinary findings and renal function was investigated for 33 Itai-Itai patients, 17 suspected patients, 235 subjects exposed to Cd and 41 subjects not exposed to Cd pollution. High correlation coefficients were observed between urinary findings and renal function in advanced cases of chronic cadmium poisoning, and multiple correlation coefficients between them are as high as 0.73 to 0.86. ..beta../sub 2/-microglobulin in urine also correlated closely with renal function and age in slight to moderate cases of cadmium poisoning. It is concluded that urinary findings such as proteinuria, glucosuria and low molecular weight proteinuria are good indicators of renal dysfunction in moderate to severe cases of cadmium poisoning. In slight to moderate cases ..beta../sub 2/-microglobulin in urine has a close relation with renal dysfunction. 7 references, 2 figures, 8 tables.

• Research Organization: Kanazawa Medical Univ., Japan
• OSTI ID: 5761775
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 54; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
BIOLOGICAL FUNCTIONS
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CADMIUM
CHRONIC EXPOSURE
DATA
ELEMENTS
FUNCTIONS
INFORMATION
INJURIES
KIDNEYS
MATERIALS
METALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
STATISTICAL DATA
TOXICITY
URINE
WASTES