Oxidative destruction of hydrazines produces N-nitrosamines and other mutagenic species

Journal Article · Sun Jun 01 04:00:00 EDT 1986 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668691389874· OSTI ID:6754556

Castegnaro, M; Brouet, I; Michelon, J; Lunn, G; Sansone, E B

As part of the joint International Agency for Research on Cancer-National Cancer Institute program for the evaluation and development of methods for the degradation of chemical carcinogens, four oxidative techniques for the degradation of hydrazines were investigated. The oxidizing agents used were as follows: sodium hypochlorite, calcium hypochlorite, potassium iodate, and potassium permanganate in sulfuric acid. In each case, at least 99% of the hydrazine initially present was destroyed; however, the potential usefulness of these methods was compromised by the formation (in some reaction mixtures) of carcinogenic N-nitroso compounds and/or unknown mutagenic species. Oxidative degradation of hydrazines is recommended only for the decontamination of glassware and for the treatment of spills, for which reductive degradation methods are not suitable.

• Research Organization: International Agency for Research on Cancer, Lyon, France
• OSTI ID: 6754556
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 47:6; ISSN AIHAA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
CHEMICAL REACTIONS
DECOMPOSITION
HAZARDS
HEALTH HAZARDS
HYDRAZINE
MUTAGENS
NITROGEN COMPOUNDS
NITROSAMINES
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDATION
SYNTHESIS
TOXICITY