Chelating-agent suppression of cadmium-induced hepatotoxicity
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
The administration of sodium N-methyl-N-dithiocarboxy-D-glucamine (NaG) at 500 mg/kg, i.p., or sodium calcium diethylenetriaminepentaacetic acid (DTPA) at 632.5 mg/kg, i.p., reduces the serum enzyme levels characteristic of hepatic damage following the intravenous administration of cadmium chloride (3.5 mg CdCl/sub 2/ x 2.5H/sub 2/O/kg). Some effect on serum enzyme levels was found even when the interval between administration of cadmium chloride and that of the antagonist was as great as 4 h. The enzymes examined included aspartate aminotransferase (AST), ..gamma..-glutamyl transpeptidase (GGT), alanine aminotransferase (SGPT), and alkaline phosphatase (AP). A histopathological examination of the livers of such animals also reveals the presence of a significant protective action.
- Research Organization:
- Vanderbilt Univ., Nashville, TN (USA)
- OSTI ID:
- 6754239
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 22:3; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE PHOSPHATASE
AMINO ACIDS
AMINOTRANSFERASES
BIOLOGICAL EFFECTS
BLOOD SERUM
BODY
CADMIUM
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CARBOXYLIC ACIDS
CHELATING AGENTS
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
DRUGS
DTPA
ELEMENTS
ENZYMES
ESTERASES
GLANDS
HALIDES
HALOGEN COMPOUNDS
HYDROLASES
INJURIES
LIVER
METALS
NITROGEN TRANSFERASES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHOSPHATASES
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
TOXICITY
TRANSFERASES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE PHOSPHATASE
AMINO ACIDS
AMINOTRANSFERASES
BIOLOGICAL EFFECTS
BLOOD SERUM
BODY
CADMIUM
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CARBOXYLIC ACIDS
CHELATING AGENTS
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
DRUGS
DTPA
ELEMENTS
ENZYMES
ESTERASES
GLANDS
HALIDES
HALOGEN COMPOUNDS
HYDROLASES
INJURIES
LIVER
METALS
NITROGEN TRANSFERASES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHOSPHATASES
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
TOXICITY
TRANSFERASES