Urinary excretion of enzymes following repeated parenteral administration of cadmium to rats

Journal Article · Sun Jun 01 04:00:00 EDT 1980 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(80)90135-8· OSTI ID:6637336

Bonner, F W; King, L J; Parke, D V

The effect of daily parenteral administration of cadmium (0.75, 1.5, and 3.0 mg/kg) on the urinary excretion of enzymes has been studied in the young male rat. Aspartate aminotransferase, alkaline phosphatase, ..gamma..-glutamyl transpeptidase, and leucine aminopeptidase all showed an initial significant increase around the second day of dosage, the intensity of which was dose related. A second phase of enzymuria occurred later, the onset of which was dose related. High-dose-group animals (3.0 mg/kg) exhibited this increase around Day 15, while the median (1.5 mg/kg) and low- (0.75 mg/kg)dose-group animals developed enzymuria around Days 21 and 38, respectively. This second phase of elevated enzyme levels in the urine was persistent, and is believed to represent the development of renal damage.

• Research Organization: Univ. of Surrey, Guildford
• OSTI ID: 6637336
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 22:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CADMIUM
CLEARANCE
ELEMENTS
ENZYMES
EXCRETION
KIDNEYS
MAMMALS
METALS
ORGANS
RATS
RODENTS
URINARY TRACT
VERTEBRATES