Effect of glucocorticoids and gamma radiation on epidermal Langerhans cells
Journal Article
·
· J. Invest. Dermatol.; (United States)
The effect of 750 rads of gamma radiation on the rate of return of epidermal Langerhans cells (LC) following suppressive doses of topical glucorticoids was studied in guinea pigs. Gamma radiation alone had no effect on the LC as assessed by staining for cell membrane ATPase activity and Ia antigen. It did, however, delay the expected return of Ia but not ATPase surface markers on the LC after perturbation with glucocorticoids. The delayed return of surface Ia antigen is possibly related to a radiation-induced defect in the production of a required lymphokine and/or in intracellular Ia transport. Although our data do not rule out a cytolytic effect of steroids on the LC, they do strongly suggest that, at least in part, glucocorticoids act on the LC by altering cell surface characteristics.
- Research Organization:
- New York Univ. Medical Center, New York
- OSTI ID:
- 6748516
- Journal Information:
- J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 82:2; ISSN JIDEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
The effect of 8-methoxypsoralen and long-wave ultraviolet light on Langerhans cell
Oxygen intermediates are involved in ultraviolet radiation-induced damage of Langerhans cells
ATPase and morphologic changes induced by UVB on Langerhans cells in guinea pigs
Journal Article
·
Thu Oct 01 00:00:00 EDT 1981
· J. Invest. Dermatol.; (United States)
·
OSTI ID:5448839
Oxygen intermediates are involved in ultraviolet radiation-induced damage of Langerhans cells
Journal Article
·
Mon Jun 01 00:00:00 EDT 1987
· J. Invest. Dermatol.; (United States)
·
OSTI ID:6328276
ATPase and morphologic changes induced by UVB on Langerhans cells in guinea pigs
Journal Article
·
Thu Aug 01 00:00:00 EDT 1985
· J. Invest. Dermatol.; (United States)
·
OSTI ID:5017438
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID ANHYDRASES
ADRENAL HORMONES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTIGENS
ATP-ASE
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL CONSTITUENTS
CELL MEMBRANES
CORTICOSTEROIDS
ELECTROMAGNETIC RADIATION
ENZYMES
EPIDERMIS
EPITHELIUM
GAMMA RADIATION
GLUCOCORTICOIDS
GUINEA PIGS
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
IONIZING RADIATIONS
KETONES
MAMMALS
MEMBRANES
ORGANIC COMPOUNDS
ORGANS
PHOSPHOHYDROLASES
PREGNANES
RADIATION EFFECTS
RADIATIONS
RODENTS
SKIN
SOMATIC CELLS
STEROID HORMONES
STEROIDS
TISSUES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID ANHYDRASES
ADRENAL HORMONES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTIGENS
ATP-ASE
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL CONSTITUENTS
CELL MEMBRANES
CORTICOSTEROIDS
ELECTROMAGNETIC RADIATION
ENZYMES
EPIDERMIS
EPITHELIUM
GAMMA RADIATION
GLUCOCORTICOIDS
GUINEA PIGS
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
IONIZING RADIATIONS
KETONES
MAMMALS
MEMBRANES
ORGANIC COMPOUNDS
ORGANS
PHOSPHOHYDROLASES
PREGNANES
RADIATION EFFECTS
RADIATIONS
RODENTS
SKIN
SOMATIC CELLS
STEROID HORMONES
STEROIDS
TISSUES
VERTEBRATES