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Critical role of extracellular calcium in vanadate-induced renal vasoconstriction

Journal Article · · Am. J. Physiol.; (United States)
OSTI ID:6748168
; ;
Intra-arterial infusion of vanadate (VO/sub 4/) in dogs produces a reduction in renal blood flow (RBF), glomerular filtration rate (GFR), urine flow (V), and the fractional excretion of sodium (FE/sub Na/sup +//). To evaluate the role of Ca/sup 2 +/ in these changes VO/sub 4/ was infused into the renal artery in the presence of the calcium antagonists trifluoperazine (TFP), verapamil, or EGTA. TFP inhibited the effect of VO/sub 4/ on RBF (TFP + VO/sub 4/: 64.1, VO/sub 4/: 38.5 ml/min; P < 0.05), GFR (TFP + VO/sub 4/: 22.9, VO/sub 4/: 9.3, ml/min; P < 0.05) and V (TFP + VO/sub 4/: 0.80, VO/sub 4/: 0.38 ml/min; P < 0.05) without changing FE/sub Na/sup +// (TFP + VO/sub 4/: 3.8, VO/sub 4/: 3.2%). Similar changes were obtained with verapamil as well as with EGTA. Furthermore thyroparathyroidectomy (TPTX) decreased serum calcium (control: 8.78, TPTX: 4.98 mg/100ml; P < 0.05) and blunted the effects of VO/sub 4/ on renal hemodynamics. Reestablishing normal serum Ca/sup 2 +/ by an intra-arterial infusion of CaCl/sub 2/ elicited the VO/sub 4/ effects of vasoconstriction and decreased GFR; V was not affected and FE/sub Na/sup +// rose. The data support the idea that influx of extracellular calcium into smooth muscle cells mediates the hemodynamic effects of VO/sub 4/ in the dog. 34 references.
Research Organization:
Univ. of Puerto Rico School of Medicine, San Juan
OSTI ID:
6748168
Journal Information:
Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 246:3; ISSN AJPHA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METALS
ALKALINE EARTH METALS
ANIMALS
ATP
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
CALCIUM
DOGS
ELEMENTS
INHIBITION
KIDNEYS
KINETICS
MAMMALS
METALS
MUSCLES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
POTASSIUM
REACTION KINETICS
RESPONSE MODIFYING FACTORS
SODIUM
TRANSITION ELEMENT COMPOUNDS
VANADATES
VANADIUM COMPOUNDS
VASOCONSTRICTION
VERTEBRATES