Effects of adenosine infusion into renal interstitium on renal hemodynamics
This study was designed to investigate the hemodynamic effects of exogenous adenosine in the interstitium of the rat kidney. Adenosine or its analogues were infused into the renal interstitium by means of chronically implanted capsules. In fusion of adenosine decreased glomerular filtration rate (GFR) from 0.81 +/- 0.06 to 0.37 +/- 0.06 ml/min while having no effect on renal blood flow (RBF). The metabolically stable analogue, 2-chloradenosine (2-ClAdo), decreased GFR from 0.73 +/- 0.07 to 021 +/- 0.06 ml/min. Interstitial infusion of theophylline, an adenosine receptor antagonist, completely abolished the effects of adenosine and 2-ClAdo on GFR. The distribution of adenosine, when infused into the renal interstitium, was determined using radiolabeled 5'-(N-ethyl)-carboxamidoadenosine (NECA), a metabolically stable adenosine agonist. After continuous infusion, (/sup 3/H)NECA was distributed throughout the kidney. The effects of NECA to reduce GFR were similar to those of adenosine and 2-ClAdo. They conclude that increased levels of adenosine in the renal interstitium markedly decrease GFR without affecting RBF in steady-state conditions. The marked effects of adenosine agonists during their infusion into the renal interstitium and the complete blockade of these effects by theophylline suggest an extracellular action of adenosine.
- Research Organization:
- Mayo Medical School, Rochester, MN
- OSTI ID:
- 5765401
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 252:4
- Country of Publication:
- United States
- Language:
- English
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NUCLEOSIDES
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TRITIUM COMPOUNDS
ADENOSINE
GLOMERULI
INFUSION
INULIN
KIDNEYS
RATS
RENAL CLEARANCE
ULTRAFILTRATION
ANIMALS
BODY
CARBOHYDRATES
CLEARANCE
DISTRIBUTION
EXCRETION
FILTRATION
INTAKE
LABELLED COMPOUNDS
MAMMALS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RIBOSIDES
RODENTS
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SEPARATION PROCESSES
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551001* - Physiological Systems- Tracer Techniques