Mechanisms controlling renal hemodynamics and electrolyte excretion during amino acids
Our purpose was to investigate the mechanisms by which increased plasma amino acids elevate renal blood flow (RBF) and glomerular filtration rate (GFR). Since transport of amino acids and Na is linked in the proximal tubule, the authors hypothesized that increased amino acids might stimulate proximal tubular Na reabsorption (PR/sub Na/) and thus increase RBF and GFR by a macula densa feedback mechanism. A solution of four amino acids (Ala, Ser, Gly, Pro) was infused intravenously into anesthetized dogs with normal kidneys (NK) and with kidneys in which the tubuloglomerular feedback mechanism was blunted by lowering renal artery pressure (LPK) or blocked by making the kidneys nonfiltering (NFK). In NK, RBF and GFR increased by 35 +/- 4% and 30 +/- 7% after 90 min of amino acid infusion, while PR/sub Na/ (estimated from lithium clearance) and O2 consumption increased by 31 +/- 5% and 29 +/- 5% and distal Na delivery remained relatively constant. Autoregulation of RBF and GFR in response to step deceases in renal artery pressure was impaired during amino acids in NK. The hemodynamic responses to amino acids were abolished in LPK and NFK. Infusion of the nonmetabolized -aminoisobutyric acid into NK produced changes in renal hemodynamics that were similar to the responses observed with the four metabolizable amino acids. These data are consistent with the hypothesis that elevation of plasma amino acids increases RBF and GFR by a mechanism that requires an intact macula densa feedback. Metabolism of the amino acids does not appear to be necessary for these changes to occur.
- Research Organization:
- Univ. of Mississippi Medical Center, Jackson
- OSTI ID:
- 6151923
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 251:2
- Country of Publication:
- United States
- Language:
- English
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AMINO ACIDS
BIOCHEMISTRY
ELECTROLYTES
RENAL CLEARANCE
IODINE 125
KIDNEYS
DYNAMIC FUNCTION STUDIES
ABSORPTION
BLOOD FLOW
DOGS
EXCRETION
FILTRATION
GLOMERULI
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ORGANIC IODINE COMPOUNDS
SODIUM COMPOUNDS
ALKALI METAL COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
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CHARGED PARTICLES
CHEMISTRY
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DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
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ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
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551001* - Physiological Systems- Tracer Techniques