Latent period and antigenicity of murine tumors induced in C3H mice by short-wavelength ultraviolet radiation

Journal Article · Sat Oct 01 04:00:00 EDT 1983 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12519921· OSTI ID:6748100

Lill, P H

Skin tumors were induced in C3H/HeNCr1BR mice with chronic short-wavelength ultraviolet (UVC) irradiation using a germicidal lamp (254 nm). Fifty percent of mice had developed tumors by 9 1/2 months (range 8-12 months). With progressive irradiation, mice developed multiple tumors on the back reaching a mean of 2.9 tumors/mouse at 11 1/2 months. No tumors developed on the ears. Of 83 lesions examined histologically 66 (80%) were squamous cell carcinomas, 6 (7%) were fibrosarcomas, and 10 (12%) were proliferative squamous lesions without evident invasion. Twenty-two squamous cell carcinomas were transplanted s.c. into normal syngeneic mice and into mice immunosuppressed by adult thymectomy, lethal x-irradiation, and bone marrow or neonatal liver reconstitution. Transplantation of squamous cell carcinomas was successful in a total of 17/22 (77%) cases. Only 11/22 (50%) tumors grew progressively in normal mice. Six of 22 (27%) tumors grew progressively in immunosuppressed mice but not normal syngeneic recipients. Three fibrosarcomas were also transplanted. All 3 grew progressively in immunosuppressed hosts but failed to grow in normal syngeneic recipients. Two fibrosarcomas that were induced by a germicidal lamp were found to grow significantly better in UVB-irradiated (280-320 nm) mice than in normal mice. Conversely, a UVB-induced fibrosarcoma showed enhanced growth in UVC-irradiated mice compared to growth in normal, age-matched controls.

• OSTI ID: 6748100
• Journal Information: J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 81:4; ISSN JIDEA
• Country of Publication: United States
• Language: English

Related Subjects

560152 -- Radiation Effects on Animals-- Animals
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
IMMUNOSUPPRESSION
IONIZING RADIATIONS
MAMMALS
MICE
NEOPLASMS
ORGANS
PATHOGENESIS
RADIATIONS
RADIOINDUCTION
RODENTS
SKIN
ULTRAVIOLET RADIATION
VERTEBRATES
X RADIATION