Marrow-tumor interactions: the role of the bone marrow in controlling chemically induced tumors

Technical Report · Tue Jan 01 04:00:00 EST 1980

DOI:https://doi.org/10.2172/6746612· OSTI ID:6746612

Rosse, C

This report summarizes work done to evaluate the role of the bone marrow in tumor growth regulation. Work done with the MCA tumor showed that several subclasses of mononuclear bone marrow cells (e.g. natural regulatory cell, NRC) play a major role in the regulation of tumor growth. Experiments with the spontaneous CE mammary carcinoma system illustrate that a rapid growth of certain neoplasms may be due to the fact that through some as yet undefined mechanism the tumor eliminates mononuclear cells in the bone marrow of the host and stops their production. (KRM)

• Research Organization: Washington Univ., Seattle (USA). Dept. of Biological Structure
• Sponsoring Organization: USDOE
• DOE Contract Number: AT06-79EV10270
• OSTI ID: 6746612
• Report Number(s): DOE/EV/10270-1
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW CELLS
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DISEASES
GLANDS
GROWTH
IMMUNITY
IN VITRO
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAMMARY GLANDS
MATERIALS
MICE
NEOPLASMS
ORGANS
RODENTS
SOMATIC CELLS
SYNERGISM
VERTEBRATES