SPECT gallium-67 scanning in early human immunodeficiency virus (HIV) infection. Failure of scanning abnormalities to correlate with immunologic staging

Journal Article · Tue May 01 04:00:00 EDT 1990 · Clinical Nuclear Medicine; (USA)

DOI:https://doi.org/10.1097/00003072-199005000-00003· OSTI ID:6743882

Anders, G T; Timmons, J H; Johnson, J E; Blanton, H M; Hartshorne, M F ^[1]

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1. Brooke Army Medical Center, Fort Sam Houston, TX (USA)

The use of gallium scanning in the treatment of patients with AIDS has been well described. In this study, 27 HIV-infected patients (Walter Reed Staging Classification I-V) with normal chest roentgenograms were evaluated to determine the occurrence of thoracic gallium abnormalities in early HIV infection. SPECT was used for gallium scanning. Patients received gallium injection on day 1 and bronchoalveolar lavage on day 2, and scanning was performed on day 3. Twenty-eight scans in 27 patients were performed. Mean nodal SPECT activity was compared with corresponding values for lung parenchyma, bronchoalveolar lavage cell counts, and peripheral blood T4 lymphocyte counts. No relationship between nodal and parenchymal activity and cell counts was observed. Although visual scan interpretation was unaffected, gallium activity was significantly increased in the region of bronchoalveolar lavage compared with uptake in other lung regions. It is concluded that SPECT gallium scanning demonstrates significant gallium avidity in recently lavaged lung areas, although no impact on visual scan interpretation was seen. Further, no correlation was seen between the degree of nodal uptake and the immunologic status of these patients with early HIV infection.

• OSTI ID: 6743882
• Journal Information: Clinical Nuclear Medicine; (USA), Journal Name: Clinical Nuclear Medicine; (USA) Vol. 15:5; ISSN CNMED; ISSN 0363-9762
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AIDS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
COMPUTERIZED TOMOGRAPHY
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
GALLIUM 67
GALLIUM ISOTOPES
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LAVAGE
LEUKOCYTES
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOGENESIS
PATIENTS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SCINTISCANNING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SOMATIC CELLS
TOMOGRAPHY
VERTEBRATES
VIRAL DISEASES