Sarcoidosis: correlation of pulmonary parenchymal pattern at CT with results of pulmonary function tests

Journal Article · Thu Jun 01 04:00:00 EDT 1989 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.171.3.2717731· OSTI ID:6029109

Bergin, C J; Bell, D Y; Coblentz, C L; Chiles, C; Gamsu, G; MacIntyre, N R; Coleman, R E; Putman, C E

The appearances of the lungs on radiographs and computed tomographic (CT) scans were correlated with degree of uptake on gallium scans and results of pulmonary function tests (PFTs) in 27 patients with sarcoidosis. CT scans were evaluated both qualitatively and quantitatively. Patients were divided into five categories on the basis of the pattern of abnormality at CT: 1 = normal (n = 4); 2 = segmental air-space disease (n = 4); 3 = spherical (alveolar) masslike opacities (n = 4); 4 = multiple, discrete, small nodules (n = 6); and 5 = distortion of parenchymal structures (fibrotic end-stage sarcoidosis) (n = 9). The percentage of the volume judged to be abnormal (CT grade) was correlated with PFT results for each CT and radiographic category. CT grades were also correlated with gallium scanning results and percentage of lymphocytes recovered from bronchoalveolar lavage (BAL). Patients in CT categories 1 and 2 had normal lung function, those in category 3 had mild functional impairment, and those in categories 4 and 5 showed moderate to severe dysfunction. The overall CT grade correlated well with PFT results expressed as a percentage of the predicted value. In five patients, CT scans showed extensive parenchymal disease not seen on radiographs. CT grades did not correlate with the results of gallium scanning or BAL lymphocytes. The authors conclude that patterns of parenchymal sarcoidosis seen at CT correlate with the PFT results and can be used to indicate respiratory impairment.

• Research Organization: Duke Univ. Medical Center, Durham, NC (USA)
• OSTI ID: 6029109
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 171:3; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BIOMEDICAL RADIOGRAPHY
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DYNAMIC FUNCTION STUDIES
FIBROSIS
GALLIUM ISOTOPES
IMAGE PROCESSING
ISOTOPES
LAVAGE
LEUKOCYTES
LUNGS
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MEDICINE
MEMBRANES
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PLEURA
PRIMATES
PROCESSING
RADIOISOTOPE SCANNING
RADIOLOGY
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SEROUS MEMBRANES
SOMATIC CELLS
VERTEBRATES