Stimulation of ultraviolet-induced carcinogenesis by 1,3-bis(2-chloroethyl)-1-nitrosourea

Journal Article · Thu Feb 01 00:00:00 EST 1979 · Cancer Res.; (United States)

OSTI ID:6739195

Epstein, J H

The influence of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on ultraviolet-induced carcinogenesis was examined in hairless mouse skin in vivo. Noncarcinogenic amounts of topically applied BCNU and carcinogenic levels of UVB energy were utilized in the study. The applications of BCNU significantly accelerated the appearance and growth of the cutaneous tumors in this study. Thus, the BCNU acted as either a promoting or a cocarcinogenic agent for ultraviolet-induced cancer formation. Although the mechanism of this effect has not been established, avoidance of extensive sun exposure would probably be prudent when topical BCNU is being utilized therapeutically.

• Research Organization: Univ. of California School of Medicine, San Francisco
• OSTI ID: 6739195
• Journal Information: Cancer Res.; (United States), Vol. 39:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOGENESIS
RADIOINDUCTION
NITROSO COMPOUNDS
EVALUATION
SKIN
BIOLOGICAL RADIATION EFFECTS
FAR ULTRAVIOLET RADIATION
MICE
NEOPLASMS
TUMOR PROMOTERS
UREA
AMIDES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBONIC ACID DERIVATIVES
DISEASES
ELECTROMAGNETIC RADIATION
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PROMOTERS
RADIATION EFFECTS
RADIATIONS
RODENTS
ULTRAVIOLET RADIATION
VERTEBRATES
560152* - Radiation Effects on Animals- Animals