Stimulation of ultraviolet-induced carcinogenesis by 1,3-bis(2-chloroethyl)-1-nitrosourea
Journal Article
·
· Cancer Res.; (United States)
OSTI ID:6739195
The influence of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on ultraviolet-induced carcinogenesis was examined in hairless mouse skin in vivo. Noncarcinogenic amounts of topically applied BCNU and carcinogenic levels of UVB energy were utilized in the study. The applications of BCNU significantly accelerated the appearance and growth of the cutaneous tumors in this study. Thus, the BCNU acted as either a promoting or a cocarcinogenic agent for ultraviolet-induced cancer formation. Although the mechanism of this effect has not been established, avoidance of extensive sun exposure would probably be prudent when topical BCNU is being utilized therapeutically.
- Research Organization:
- Univ. of California School of Medicine, San Francisco
- OSTI ID:
- 6739195
- Journal Information:
- Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 39:2; ISSN CNREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBONIC ACID DERIVATIVES
CARCINOGENESIS
DISEASES
ELECTROMAGNETIC RADIATION
EVALUATION
FAR ULTRAVIOLET RADIATION
MAMMALS
MICE
NEOPLASMS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PROMOTERS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SKIN
TUMOR PROMOTERS
ULTRAVIOLET RADIATION
UREA
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBONIC ACID DERIVATIVES
CARCINOGENESIS
DISEASES
ELECTROMAGNETIC RADIATION
EVALUATION
FAR ULTRAVIOLET RADIATION
MAMMALS
MICE
NEOPLASMS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PROMOTERS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SKIN
TUMOR PROMOTERS
ULTRAVIOLET RADIATION
UREA
VERTEBRATES