Effects of mechlorethamine (HN/sub 2/, nitrogen mustard) on UV-induced carcinogenesis in hairless mouse skin
Journal Article
·
· J. Natl. Cancer Inst.; (United States)
OSTI ID:6748148
The influence of mechlorethamine (HN/sub 2/, nitrogen mustard) on UV-induced carcinogenesis was examined in the hairless mouse skin in vivo. Noncarcinogenic amounts of topically applied HN/sub 2/ and carcinogenic levels of UVB energy were used in the study. The HN/sub 2/ applications significantly accelerated the appearance and growth of cutaneous tumors in this study. Thus HN/sub 2/ acted as either a promoter or cocarcinogen for UV-induced cancer formation. Although the mechanism of this effect was not established, combinations of UVB radiation and HN2 topical therapy pointed to an increased incidence of cutaneous tumors in human skin.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 6748148
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 72:2; ISSN JNCIA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
560400 -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
CARCINOMAS
DISEASES
ELECTROMAGNETIC RADIATION
MAMMALS
MICE
NEOPLASMS
NITROGEN MUSTARD
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PATHOGENESIS
PROMOTERS
RADIATION EFFECTS
RADIATIONS
RODENTS
SKIN
SYNERGISM
TUMOR PROMOTERS
ULTRAVIOLET RADIATION
VERTEBRATES
560400 -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
CARCINOMAS
DISEASES
ELECTROMAGNETIC RADIATION
MAMMALS
MICE
NEOPLASMS
NITROGEN MUSTARD
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PATHOGENESIS
PROMOTERS
RADIATION EFFECTS
RADIATIONS
RODENTS
SKIN
SYNERGISM
TUMOR PROMOTERS
ULTRAVIOLET RADIATION
VERTEBRATES