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Inhibition of ultraviolet-B skin carcinogenesis by all-trans-retinoic acid regimens that inhibit ornithine decarboxylase induction

Journal Article · · Cancer Res.; (United States)
OSTI ID:6522915
; ; ;
There is a correlation between the ability to induce the polyamine-biosynthetic enzyme ornithine decarboxylase (ODC) and the tumor-promoting ability of various carcinogens in mouse epidermis. Some agents which inhibit skin carcinogenesis also inhibit ODC induction. In this study, all-trans-retinoic acid (RA) regimens that inhibited the induction of epidermal ODC by ultraviolet-B (UVB) were tested for their ability to inhibit UVB skin carcinogenesis. Hairless mice were irradiated once daily with UVB for 20 days, receiving a total dose of UVB (17.1 kJ/sq m). Topical RA was applied immediately (RA, one dose) or applied 0, 1, 2, 3, and 4 hr (RA, five doses) after each irradiance. The mice were maintained for 52 weeks and then sacrificed. Groups treated with RA tended to have fewer mice with tumors, fewer tumors per mouse, smaller tumor diameters, and slower growing tumors than did appropriate irradiated control groups. RA given five times was more effective than was RA given one time at inhibiting UVB skin carcinogenesis. These results show that RA treatments that inhibit epidermal ODC induction may be effective in reducing the carcinogenicity of UVB.
Research Organization:
Division of Dermatology, Department of Medicine, UCLA, Los Angeles, California
OSTI ID:
6522915
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 43:1; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

550200 -- Biochemistry
550900 -- Pathology
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBON-CARBON LYASES
CARBOXY-LYASES
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CARCINOGENESIS
DECARBOXYLASES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
ESTERS
LYASES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
ORNITHINE
PATHOGENESIS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RETINOIC ACID
SKIN
ULTRAVIOLET RADIATION