Differential retinoic acid inhibition of ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate and by germicidal ultraviolet light

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Cancer Res.; (United States)

OSTI ID:6008083

Lichti, U; Patterson, E; Hennings, H; Yuspa, S H

Several retinoids including retinoic acid effectively inhibit phorbol ester-mediated tumor promotion and ornithine decarboxylase (ODC) induction in mouse epidermis. To understand better the possible cellular site of action of retinoids, the inhibitory action of retinoic acid on the induction of ODC was compared for two distinctly different inducers, namely, 12-O-tetradecanoylphorbol-13-acetate (TPA) and germicidal ultraviolet light (uv), in primary mouse epidermal cell cultures. It was found that the induction of ODC by TPA is almost completely prevented by retinoic acid while the induction by uv is only moderately inhibited. The differential inhibition of enzyme induction cannot be accounted for by selective retinoid inhibition of DNA, RNA, or protein synthesis either alone or in concert with TPA or uv. These agents possibly act at transcription or translation, both of which are required for ODC induction by TPA or uv.

• OSTI ID: 6008083
• Journal Information: Cancer Res.; (United States), Vol. 41:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOSYNTHESIS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
INHIBITION
DECARBOXYLASES
CAROTENOIDS
EPIDERMIS
MICE
PHORBOL ESTERS
ULTRAVIOLET RADIATION
ANIMAL TISSUES
ANIMALS
BODY
CARBON-CARBON LYASES
CARBOXY-LYASES
CARCINOGENS
ELECTROMAGNETIC RADIATION
ENZYMES
EPITHELIUM
ESTERS
HYDROCARBONS
LYASES
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PIGMENTS
RADIATION EFFECTS
RADIATIONS
RODENTS
SKIN
SYNTHESIS
TERPENES
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals