Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Tumor-promoting phorbol ester amplifies the inductions of tyrosine aminotransferase and ornithine decarboxylase by glucocorticoid

Journal Article · · Biochemistry; (United States)
DOI:https://doi.org/10.1021/bi00382a041· OSTI ID:5596219
; ;
In adrenalectomized rats, the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the inductions of tyrosine aminotransferase (TAT) and ornithine decarboxylase by glucocorticoids, even with sufficient concentration of glucocorticoids to have a maximal effect, whereas it had no effect on TAT activity and increased ornithine decarboxylase activity only slightly in the absence of glucocorticoids. Phorbol derivatives and components of TPA such as 4..beta..-phorbol, phorbol 12-tetradecanoate, phorbol 13-acetate, and 4-O-methylphorbol 12-tetradecanoate 13-acetate, which have no tumor-promoting activity or ability to activate protein kinase C, did not have any effect on TAT induction by glucocorticoid. TPA enhanced the induction of TAT by various glucocorticoids but had no effect on induction of TAT by glucagon or insulin and did not enhance the induction of glucose-6-phosphate dehydrogenase by 17..beta..-estradiol. These results suggest that TPA specifically enhances the induction of TAT and ornithine decarboxylase by glucocorticoids. Similar effects of TPA on TAT induction by glucocorticoid were observed in primary cultures of adult rat hepatocytes. Another activator of protein kinase C, rac-1,2-dioctanoylglycerol, was also found to have similar effects on the cells.
Research Organization:
Univ. of Tokushima, Japan
OSTI ID:
5596219
Journal Information:
Biochemistry; (United States), Journal Name: Biochemistry; (United States) Vol. 26:8; ISSN BICHA
Country of Publication:
United States
Language:
English

Similar Records

Inhibition of phorbol ester-induced polyamine accumulation in mouse epidermis by anti-inflammatory steroid
Journal Article · Thu Dec 27 23:00:00 EST 1979 · Biochem. Biophys. Res. Commun.; (United States) · OSTI ID:6407826
Retinoic acid modulation of ultraviolet light-induced epidermal ornithine decarboxylase activity
Journal Article · Sun Jan 31 23:00:00 EST 1982 · J. Invest. Dermatol.; (United States) · OSTI ID:5474991
Dissociation of tumor promoter-stimulated ornithine decarboxylase activity and DNA synthesis in mouse epidermis in vivo and in vitro by fluocinolone acetonide, a tumor-promotion inhibitor
Journal Article · Thu Sep 01 00:00:00 EDT 1977 · Proc. Natl. Acad. Sci. U.S.A.; (United States) · OSTI ID:7091527

Related Subjects

550201 -- Biochemistry-- Tracer Techniques
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
AMINOTRANSFERASES
ANIMALS
BIOLOGICAL EFFECTS
CARBON 14 COMPOUNDS
CARBON-CARBON LYASES
CARBOXY-LYASES
CARCINOGENS
CORTICOSTEROIDS
DECARBOXYLASES
DEXAMETHASONE
DOSE-RESPONSE RELATIONSHIPS
ENZYME ACTIVITY
ENZYME INDUCTION
ENZYMES
ESTERS
GENE REGULATION
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
KETONES
LABELLED COMPOUNDS
LYASES
MAMMALS
NITROGEN TRANSFERASES
ORGANIC COMPOUNDS
PHORBOL ESTERS
PREGNANES
PROMOTERS
RATS
RODENTS
STEROID HORMONES
STEROIDS
TRANSFERASES
TUMOR PROMOTERS
VERTEBRATES