Effect of Manganese on some aspects of carbohydrate metabolism in rats. [None]
Numerous biochemical and toxicological studies have indicated that chronic exposure to manganese leads to neurological abnormalities. Increasing use of manganese compounds as antiknocks in gasoline and diesel fuel has aroused a great concern over the toxicological potential of this metal and stressed the need for understanding the mechanism of its poisoning. Reports of alerations in the levels of biogenic amines have helped in understanding the basis of neurological disorders. However, little is known about the mechanism by which manganese exposure leads to hypoglycemia in workers. This study deals with the influence of manganese exposure on metabolism of glucose, the chief fuel of the brain, and some enzymes involved in its oxidation. These studies will provide an assessment of the extent to which manganese affects the various processes controlling carbohydrate metabolism.
- Research Organization:
- Industrial Toxicology Research Center, Lucknow, India
- OSTI ID:
- 6737619
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 25:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BLOOD
QUANTITATIVE CHEMICAL ANALYSIS
GLUCOSE
METABOLISM
LIVER
MANGANESE
BIOLOGICAL EFFECTS
BIOASSAY
BIOCHEMICAL REACTION KINETICS
BRAIN
ENZYME ACTIVITY
GLYCOGEN
HYPERGLYCEMIA
OXIDATION
RATS
TIME DEPENDENCE
TOXICITY
ALDEHYDES
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CHEMICAL ANALYSIS
CHEMICAL REACTIONS
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
HEXOSES
KINETICS
MAMMALS
MATERIALS
METALS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
REACTION KINETICS
RODENTS
SACCHARIDES
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550200 - Biochemistry