Health assessment document for manganese. Final report
Technical Report
·
OSTI ID:6165224
The document evaluates data on occurrence, sources, and transport of manganese in the environment and data on metabolism, pharmacokinetics, laboratory toxicological and epidemiologic studies to determine the nature and dose response relationship of potential health effects on humans. Nationwide air sampling data indicate that mean manganese concentrations have declined from 0.11 micrograms per cu. m. in 1953-1957 to 0.033 micrograms per cu. m. in 1982. The effects of major concern to humans exposed to manganese are on neurological and on pulmonary function. The CNS effects have been observed in humans at exposure levels above 5 mg/cu. m. and are incapacitating and generally irreversible. Data are equivocal between 1 and 5 mg/cu. m. but suggest decreased prevalence. There are no reports of these effects below 0.3 mg/cu. m. exposure. Pneumonia and chronic bronchitis occur at levels which are associated with neurological effects. Reduced lung function has been reported in children exposed to an estimated 3-11 micrograms per cu. m. from emission of a ferromanganese plant. However, studies of workers exposed to 40 micrograms per cu. m. did not show respiratory symptoms. Animal studies qualitatively support pulmonary effects of manganese exposure. Respiratory symptoms occur at lower levels than neurological symptoms and are therefore considered to be the critical effect based on available data.
- Research Organization:
- Environmental Protection Agency, Cincinnati, OH (USA). Office of Environmental Criteria and Assessment
- OSTI ID:
- 6165224
- Report Number(s):
- PB-84-229954; EPA/600-8-83/013F
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of sulfur oxide pollutants on respiratory function, particle deposition and bronchial clearance. Final report
Respiratory morbidity of pattern and model makers exposed to wood, plastic, and metal products
Health implications of increased manganese in the environment resulting from the combustion of fuel additives: a review of the literature
Technical Report
·
Fri Oct 31 23:00:00 EST 1980
·
OSTI ID:5805721
Respiratory morbidity of pattern and model makers exposed to wood, plastic, and metal products
Journal Article
·
Sun Dec 31 23:00:00 EST 1989
· American Journal of Industrial Medicine; (USA)
·
OSTI ID:6936571
Health implications of increased manganese in the environment resulting from the combustion of fuel additives: a review of the literature
Journal Article
·
Sat Dec 31 23:00:00 EST 1983
· J. Toxicol. Environ. Health; (United States)
·
OSTI ID:6003745
Related Subjects
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ECOLOGICAL CONCENTRATION
ELEMENTS
ENVIRONMENTAL TRANSPORT
EPIDEMIOLOGY
HAZARDS
HEALTH HAZARDS
MANGANESE
MASS TRANSFER
METABOLISM
METALS
POLLUTION
POLLUTION SOURCES
PUBLIC HEALTH
TOXICITY
TRANSITION ELEMENTS
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ECOLOGICAL CONCENTRATION
ELEMENTS
ENVIRONMENTAL TRANSPORT
EPIDEMIOLOGY
HAZARDS
HEALTH HAZARDS
MANGANESE
MASS TRANSFER
METABOLISM
METALS
POLLUTION
POLLUTION SOURCES
PUBLIC HEALTH
TOXICITY
TRANSITION ELEMENTS