Heat shock and herpes virus: enhanced reactivation without untargeted mutagenesis
Journal Article
·
· Environ. Mol. Mutagen.; (United States)
Enhanced reactivation of Ultraviolet-irradiated virus has been reported to occur in heat-shocked host cells. Since enhanced virus reactivation is often accompanied by untargeted mutagenesis, we investigated whether such mutagenesis would occur for herpes simplex virus (HSV) in CV-1 monkey kidney cells subjected to heat shock. In addition to expressing enhanced reactivation, the treated cells were transiently more susceptible to infection by unirradiated HSV. No mutagenesis of unirradiated HSV was found whether infection occurred at the time of increased susceptibility to infection or during expression of enhanced viral reactivation.
- Research Organization:
- Center for Devices and Radiological Health, Rockville, MD (USA)
- OSTI ID:
- 6730069
- Journal Information:
- Environ. Mol. Mutagen.; (United States), Journal Name: Environ. Mol. Mutagen.; (United States) Vol. 12:2; ISSN ENMUE
- Country of Publication:
- United States
- Language:
- English
Similar Records
U. v. -enhanced reactivation of u. v. -irradiated herpes virus by primary cultures of rat hepatocytes
Evidence for repair of ultraviolet light-damaged herpes virus in human fibroblasts by a recombination mechanism
Inducible responses to DNA damage in the mouse embryo fibroblasts cell line C3H/10T1/2 and its transformed counterpart C3H/MCA
Journal Article
·
Sat Mar 31 23:00:00 EST 1984
· Carcinogenesis (N.Y.); (United States)
·
OSTI ID:6597529
Evidence for repair of ultraviolet light-damaged herpes virus in human fibroblasts by a recombination mechanism
Journal Article
·
Mon Sep 01 00:00:00 EDT 1980
· Virology; (United States)
·
OSTI ID:6839341
Inducible responses to DNA damage in the mouse embryo fibroblasts cell line C3H/10T1/2 and its transformed counterpart C3H/MCA
Thesis/Dissertation
·
Wed Dec 31 23:00:00 EST 1986
·
OSTI ID:6148510
Related Subjects
560130* -- Radiation Effects on Microorganisms
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL SHOCK
BODY
DISEASES
ELECTROMAGNETIC RADIATION
ENERGY
HEAT
HERPES SIMPLEX
INFECTIOUS DISEASES
KIDNEYS
MAMMALS
MICROORGANISMS
MONKEYS
MUTAGENESIS
MUTATIONS
ORGANS
PARASITES
PATHOLOGICAL CHANGES
PRIMATES
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SKIN DISEASES
ULTRAVIOLET RADIATION
VERTEBRATES
VIABILITY
VIRAL DISEASES
VIRUSES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL SHOCK
BODY
DISEASES
ELECTROMAGNETIC RADIATION
ENERGY
HEAT
HERPES SIMPLEX
INFECTIOUS DISEASES
KIDNEYS
MAMMALS
MICROORGANISMS
MONKEYS
MUTAGENESIS
MUTATIONS
ORGANS
PARASITES
PATHOLOGICAL CHANGES
PRIMATES
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SKIN DISEASES
ULTRAVIOLET RADIATION
VERTEBRATES
VIABILITY
VIRAL DISEASES
VIRUSES