skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Prolonged cold storage of red blood cells by oxygen removal and additive usage

Abstract

Prolonged cold storage of red blood cells by oxygen removal and additive usage. A cost-effective, 4 C storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. The improved in vivo survival and the preservation of adenosine triphosphate levels, along with reduction in hemolysis and membrane vesicle production of red blood cells stored at 4 C for prolonged periods of time, is achieved by reducing the oxygen level therein at the time of storage; in particular, by flushing the cells with an inert gas, and storing them in an aqueous solution which includes adenine, dextrose, mannitol, citrate ion, and dihydrogen phosphate ion, but no sodium chloride, in an oxygen-permeable container which is located in an oxygen-free environment containing oxygen-scavenging materials. 8 figs.

Inventors:
;
Publication Date:
Research Org.:
University of California
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
672690
Patent Number(s):
US 5,789,151/A/
Application Number:
PAN: 8-857,474
Assignee:
Univ. of California, Los Alamos, NM (United States)
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 4 Aug 1998
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; ERYTHROCYTES; STORAGE LIFE; TRANSFUSIONS; COLD STORAGE; ATP; OXYGEN

Citation Formats

Bitensky, M W, and Yoshida, Tatsuro. Prolonged cold storage of red blood cells by oxygen removal and additive usage. United States: N. p., 1998. Web.
Bitensky, M W, & Yoshida, Tatsuro. Prolonged cold storage of red blood cells by oxygen removal and additive usage. United States.
Bitensky, M W, and Yoshida, Tatsuro. Tue . "Prolonged cold storage of red blood cells by oxygen removal and additive usage". United States.
@article{osti_672690,
title = {Prolonged cold storage of red blood cells by oxygen removal and additive usage},
author = {Bitensky, M W and Yoshida, Tatsuro},
abstractNote = {Prolonged cold storage of red blood cells by oxygen removal and additive usage. A cost-effective, 4 C storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. The improved in vivo survival and the preservation of adenosine triphosphate levels, along with reduction in hemolysis and membrane vesicle production of red blood cells stored at 4 C for prolonged periods of time, is achieved by reducing the oxygen level therein at the time of storage; in particular, by flushing the cells with an inert gas, and storing them in an aqueous solution which includes adenine, dextrose, mannitol, citrate ion, and dihydrogen phosphate ion, but no sodium chloride, in an oxygen-permeable container which is located in an oxygen-free environment containing oxygen-scavenging materials. 8 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {8}
}