Prolonged cold storage of red blood cells by oxygen removal and additive usage

Patent · Thu Jan 01 04:00:00 EST 1998

OSTI ID:871751

Bitensky, Mark W ^[1]; Yoshida, Tatsuro ^[2]

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1. Boston, MA
2. Newton, MA

Prolonged cold storage of red blood cells by oxygen removal and additive usage. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. The improved in vivo survival and the preservation of adenosine triphosphate levels, along with reduction in hemolysis and membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time, is achieved by reducing the oxygen level therein at the time of storage; in particular, by flushing the cells with an inert gas, and storing them in an aqueous solution which includes adenine, dextrose, mannitol, citrate ion, and dihydrogen phosphate ion, but no sodium chloride, in an oxygen-permeable container which is located in an oxygen-free environment containing oxygen-scavenging materials.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM
• DOE Contract Number: W-7405-ENG-36
• Assignee: Regents of University of California (Los Alamos, NM)
• Patent Number(s): US 5789151
• OSTI ID: 871751
• Country of Publication: United States
• Language: English

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