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Title: Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas

Abstract

A method is disclosed using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4 C storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4 C for prolonged periods of time is achieved by removing oxygen from the red blood cells at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate. 4 figs.

Inventors:
;
Publication Date:
Research Org.:
University of California
OSTI Identifier:
504949
Patent Number(s):
US 5,624,794/A/
Application Number:
PAN: 8-473,675
Assignee:
Univ. of California, Los Alamos, NM (United States) PTO; SCA: 550500; PA: EDB-97:101409; SN: 97001815607
DOE Contract Number:
W-7405-ENG-36
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 29 Apr 1997
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; ERYTHROCYTES; STORAGE LIFE; OXYGEN; REMOVAL; TRANSFUSIONS; ATP; CELL MEMBRANES

Citation Formats

Bitensky, M.W., and Yoshida, Tatsuro. Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas. United States: N. p., 1997. Web.
Bitensky, M.W., & Yoshida, Tatsuro. Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas. United States.
Bitensky, M.W., and Yoshida, Tatsuro. Tue . "Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas". United States. doi:.
@article{osti_504949,
title = {Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas},
author = {Bitensky, M.W. and Yoshida, Tatsuro},
abstractNote = {A method is disclosed using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4 C storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4 C for prolonged periods of time is achieved by removing oxygen from the red blood cells at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate. 4 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 29 00:00:00 EDT 1997},
month = {Tue Apr 29 00:00:00 EDT 1997}
}