Dyes designed for high sensitivity detection of double-stranded DNA
Patent
·
OSTI ID:672559
Novel fluorescent dyes are provided, characterized by having a fluorophore joined to a cationic chain. The dyes are found to provide for high enhancement upon binding to nucleic acid and have strong binding affinities to the nucleic acid, as compared to the fluorophore without the polycationic chain. The dyes find use in detection of dsDNA in gel electrophoresis and solution at substantially higher sensitivities using substantially less dye. 10 figs.
- Research Organization:
- Univ. of California (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG03-91ER61125
- Assignee:
- Univ. of California, Berkeley, CA (United States)
- Patent Number(s):
- US 5,783,687/A/
- Application Number:
- PAN: 8-708,666
- OSTI ID:
- 672559
- Resource Relation:
- Other Information: PBD: 21 Jul 1998
- Country of Publication:
- United States
- Language:
- English
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