Kinetics of intraepithelial lymphocytes in the small intestine of thymus-deprived mice and antigen-deprived mice

Journal Article · Sat May 01 04:00:00 EDT 1976 · Anat. Rec.; (United States)

DOI:https://doi.org/10.1002/ar.1091850110· OSTI ID:6725362

Roepke, C; Everett, N B

The kinetics of lymphoid cells within the epithelium of the small gut has been studied in various thymus-deprived mice and in antigen-deprived mice by the use of /sup 3/H-thymidine injections and radioautography. In thymus-deprived mice--including adult thymectomized, thymectomized and irradiated, neonatally thymectomized, and nude mice--and in germ-free mice decreased numbers of intraepithelial lymphocytes (IL) were found. On the other hand, the radioautographic results indicated that the remaining IL populations included both newly formed and long-lived lymphoid cells in the same percentages as found in sham-operated controls and normal mice. It is concluded that although the presence of the thymus and the antigen content of the gut is of importance to the maintenance of the numbers of cells in the lymphoid populations of the intestinal wall, the basic kinetics of these cell populations are preserved in deprived mice.

• Research Organization: Univ., Copenhagen
• OSTI ID: 6725362
• Journal Information: Anat. Rec.; (United States), Journal Name: Anat. Rec.; (United States) Vol. 185:1; ISSN ANREA
• Country of Publication: United States
• Language: English

Related Subjects

550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ABUNDANCE
ANIMAL CELLS
ANIMALS
ANTIGENS
AUTORADIOGRAPHY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
EPITHELIUM
GASTROINTESTINAL TRACT
INTESTINES
KINETICS
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MEDICINE
MICE
ORGANS
RODENTS
SMALL INTESTINE
SOMATIC CELLS
SURGERY
THYMECTOMY
THYMUS
TISSUES
VERTEBRATES