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Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta

Journal Article · · Proceedings of the National Academy of Sciences of the United States of America; (USA)
DOI:https://doi.org/10.1073/pnas.88.1.43· OSTI ID:5983834
; ; ; ; ; ;  [1]
  1. Institut Pasteur, Paris (France)
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The kinetics of postnatal intestinal colonization by T cells carrying gamma delta and alpha beta T-cell antigen receptors were studied in nude and normal mice by flow cytometry and immunohistology. Furthermore, gamma delta and alpha beta T-cell development was analyzed in lethally irradiated mice that were reconstituted by fetal liver precursors with or without a thymus. Our results establish that a major subpopulation of gamma delta intestinal intraepithelial lymphocytes is produced from uncommitted precursors at extrathymic sites. This work further shows that a small pool of T cells carrying alpha beta T-cell receptors can also differentiate extrathymically from CD3- fetal liver precursors but with rates of production and peripheral expansion much reduced as compared with those observed in thymus-bearing animals.
OSTI ID:
5983834
Journal Information:
Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 88:1; ISSN PNASA; ISSN 0027-8424
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTIBODIES
ANTIGENS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL DIFFERENTIATION
CELL FLOW SYSTEMS
CHIMERAS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
EPITHELIUM
FETUSES
GASTROINTESTINAL TRACT
GLANDS
INTESTINES
IRRADIATION
LETHAL IRRADIATION
LEUKOCYTES
LIVER
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MEDICINE
MEMBRANE PROTEINS
MEMBRANES
MICE
MONOCLONAL ANTIBODIES
MOSAICISM
MUCOUS MEMBRANES
ORGANIC COMPOUNDS
ORGANS
PRECURSOR
PROTEINS
RADIATION CHIMERAS
RECEPTORS
RODENTS
SOMATIC CELLS
SPLEEN
SURGERY
THYMECTOMY
TISSUES
VERTEBRATES