Immunoreactive atrial natriuretic factor is increased in ovine model of endotoxemia

Journal Article · Fri Apr 01 04:00:00 EST 1988 · American Journal of Physiology; (USA)

OSTI ID:6724816

Lubbesmeyer, H J; Woodson, L; Traber, L D; Flynn, J T; Herndon, D N; Traber, D L ^[1]

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1. Univ. of Texas Medical Branch, Galveston (USA) Thomas Jefferson Medical College, Philadelphia, PA (USA) Westfaelian Wilhelms Univ., Muenster (West Germany)

A bolus of Escherichia coli endotoxin (1.5 {mu}g/kg) was administered to chronically instrumented sheep. Immunoreactive atrial natriuretic factor (IR-ANF) was measured in extracted plasma by radioimmunoassay. There was a thirteenfold increase in IR-ANF 2 h after endotoxin administration, and IR-ANF levels remained significantly elevated during the first 6 h. A marked diuresis and natriuresis occurred between 4 and 6 h. ANF not only affects renal function but is also associated with decreased cardiac output, increased peripheral resistance (in sheep), and decreased capillary absorption (in rats). These renal and hemodynamic changes are also characteristic of the early (first 6 h) response to endotoxin. Therefore ANF should be considered as a potential mediator of renal and hemodynamic changes induced by sepsis. It is difficult to determine if ANF elevation is an epiphenomenon or a causative factor, because no antagonist of ANF is currently available.

• OSTI ID: 6724816
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 254:4; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

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551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
ANIMALS
ANTIGENS
AZOLES
BACTERIA
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD PRESSURE
BODY
BODY FLUIDS
CLEARANCE
CREATININE
DIAGNOSTIC TECHNIQUES
DOMESTIC ANIMALS
ENDOTOXINS
ESCHERICHIA COLI
EXCRETION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMINES
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
KIDNEYS
MAMMALS
MATERIALS
MICROORGANISMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDES
POTASSIUM COMPOUNDS
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RUMINANTS
SEPTICEMIA
SHEEP
SODIUM COMPOUNDS
TOXIC MATERIALS
TOXINS
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES