Atrial natriuretic factor in maternal and fetal sheep
To determine atrial natriuretic factor (ANF) concentrations in the circulation and body fluids of adult pregnant sheep and their fetuses, pregnant ewes were anesthetized with pentobarbital sodium, and the fetuses were exteriorized for sampling. ANF concentration, as measured by radioimmunoassay, was 47 +/- 6 (SE) pg/ml in maternal plasma, which was significantly higher than the 15 +/- 3 pg/ml in maternal urine. In the fetus, plasma ANF concentration was 265 +/- 49 pg/ml, 5.6 times that in maternal plasma. No umbilical arterial and venous difference in ANF concentration was observed. Fetal urine ANF concentration was significantly lower than that in fetal plasma, and was similar to that measured in amniotic and allantoic fluid. In chronically catheterized maternal and fetal sheep, fetal plasma ANF was again 5.1 times that in maternal plasma, and these levels were not different from those measured in acutely anesthetized animals. These results demonstrate that immunoreactive ANF is present in the fetal circulation at levels higher than those found in the mother. The low concentration of ANF in fetal urine suggests that ANF is probably metabolized and/or reabsorbed by the fetal kidney.
- Research Organization:
- Univ. of California, San Diego, La Jolla
- OSTI ID:
- 6283811
- Journal Information:
- Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:2; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ANESTHESIA
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL STRESS
BIOLOGICAL WASTES
BLOOD
BLOOD CIRCULATION
BLOOD PLASMA
BODY FLUIDS
DIURETICS
DOMESTIC ANIMALS
DRUGS
FEMALES
FETUSES
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
MATERIALS
PREGNANCY
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RUMINANTS
SHEEP
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES