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Atrial distension of isolated rabbit hearts and release of atrial natriuretic factor

Journal Article · · American Journal of Physiology; (USA)
OSTI ID:6896333
;  [1]
  1. Univ. of Colorado Health Sciences Center, Denver (USA) Clinical Research Institute of Montreal, Quebec (Canada)
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Interventions that increase atrial pressures in humans or laboratory animals release atrial natriuretic factor (ANF) into the circulation. The authors studied the relation between distension of the right or left atrium and release of ANF in retrograde-perfused isolated rabbit hearts. A fluid-filled balloon within the right or left atrium was inflated to a mean pressure of 5, 10, 15, or 20 mmHg, and ANF in the cardiac effluent was measured by radioimmunoassay. The slope of the regression line relating ANF release to atrial distending pressure was steeper for the left than right atrium, indicating that, at comparable increases in mean pressures, the left atrium releases more ANF than does the right atrium. Left atrial tissue concentration ANF was greater than right atrial. In contrast to previous studies showing right atrial dominance in rats, the left atria of isolated, perfused rabbit hearts contain more ANF and release more in response to atrial distension.

OSTI ID:
6896333
Journal Information:
American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 255:2; ISSN 0002-9513; ISSN AJPHA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ANIMALS
BIOASSAY
BLOOD PRESSURE
BODY
CARDIOVASCULAR SYSTEM
CHROMATOGRAPHY
DIAGNOSTIC TECHNIQUES
DOSE-RESPONSE RELATIONSHIPS
HEART
HORMONES
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
LIQUID COLUMN CHROMATOGRAPHY
MAMMALS
ORGANS
PEPTIDE HORMONES
PERFUSED TISSUES
RABBITS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
SEPARATION PROCESSES
TISSUES
TRACER TECHNIQUES
VERTEBRATES