Radiation dosimetry of 2 (/sup 18/F)fluoro-2-deoxy-D-glucose in man

Journal Article · Thu Jul 01 04:00:00 EDT 1982 · J. Nucl. Med.; (United States)

OSTI ID:6723762

Jones, S C; Alavi, A; Christman, D; Montanez, I; Wolf, A P; Reivich, M

Bladder and brain time-activity measurements in humans were performed after the intravenous administration of 2-(/sup 18/F)fluoro-2-deoxy-D-glucose. Radiation doses were calculated using the MIRD schema. The bladder wall received an average of 440 mrad/mCi (s.e. 76) in ten subjects who voided at 2 hr after administration of tracer. If these subjects had voided at 1 hr, the bladder-wall dose would have been reduced to 220 mrad/mCi. The brain received an average of 81 mrad/mCi in eight subjects. The doses to other organs, calculated from published dog biodistribution data, are between 50 and 85 mrad/mCi except for spleen and heart, which both received 160 mrad/mCi. These time-activity measurements for the critical organ in the human avoid the assumptions made in using animal biodistribution data for human dosimetry calculations.

• Research Organization: University of Pennsylvania, Philadephia
• OSTI ID: 6723762
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLADDER
BODY
BRAIN
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DISTRIBUTION
DOSES
DOSIMETRY
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEART
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABORATORY ANIMALS
LIGHT NUCLEI
MEASURING METHODS
MICRODOSIMETRY
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RADIATION DOSES
RADIOISOTOPES
SACCHARIDES
SPLEEN
TIME DEPENDENCE
TISSUE DISTRIBUTION
URINARY TRACT