Radiation dose to the bladder wall from 2-( sup 18 F)fluoro-2-deoxy-D-glucose in adult humans

Journal Article · Mon Apr 01 04:00:00 EST 1991 · Journal of Nuclear Medicine; (USA)

OSTI ID:5643501

Dowd, M T; Chen, C T; Wendel, M J; Faulhaber, P J; Cooper, M D ^[1]

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1. Univ. of Chicago, IL (USA)

Accurate determination of the radiation dose to the bladder wall from 2-(18F)fluoro-2-deoxy-D-glucose (2-({sup 18}F)FDG) is important because the bladder is the critical organ in radiotracer studies using 2-({sup 18}F)FDG. The radiation dose to the bladder wall from injected 2-({sup 18}F)FDG was estimated using both a dynamic bladder model and the conventional MIRD model. The dynamic model takes into account the excretion rate, the varying size of the bladder, the volume at injection, and an estimated bladder time activity curve. Our data from 302 adult subjects in a five-year period indicate that when the bladder is large at the time of injection, the dose to the bladder is greatly reduced. The absorbed dose of the bladder based on the dynamic model for an initial volume of 450 ml is 0.16 +/- 0.06 rad/mCi, while that for an initial volume of 200 ml is calculated to be 0.37 +/- 0.18 rad/mCi. The MIRD model estimates an average value of 0.35 +/- 0.16 rad/mCi for the 302 cases.

• OSTI ID: 5643501
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 32:4; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLADDER
BODY
CARBOHYDRATES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOSES
DOSIMETRY
DRUGS
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MAN
MATHEMATICAL MODELS
MONOSACCHARIDES
NANOSEC LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIATION DOSES
RADIOISOTOPES
RADIOPHARMACEUTICALS
SACCHARIDES
TOMOGRAPHY
URINARY TRACT
VERTEBRATES