Absorbed doses of radiation after an intravenous injection of N-13 ammonia in man: concise communication

Journal Article · Sat Mar 01 04:00:00 EST 1980 · J. Nucl. Med.; (United States)

OSTI ID:5407630

Lockwood, A H

Using body distribution data with the MIRD tables and equations, the radiation dose delivered by an i.v. injection of N-13 ammonia has been calculated for several human organs. The liver and the urinary bladder wall receive 0.017 and 0.051 rad/mCi injected respectively; the latter can be reduced by early post-injection voiding. The brain-to-brain absorbed dose is 0.016 rad/mCi injected. The absorbed doses for the whole body, the red marrow, the ovaries, and the testes are, respectively, 0.0055, 0.0054, 0.0098, and 0.0010 rad/mCi injected. Severe liver disease is associated with a reduction in the fraction of the injected N-13 that is excreted in the urine, and thus causes a reduction in the absorbed dose to the urinary bladder wall from the bladder contents. Hepatomegaly increases the fraction of the N-13 ammonia trapped by the liver, and complicates calculation of the absorbed dose of radiation. These data should facilitate the evaluation of the risk from radiation absorption following i.v. injections of N-13 ammonia in humans.

• Research Organization: Univ. of Miami School of Medicine, FL
• OSTI ID: 5407630
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:3; ISSN JNMEA
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLADDER
BODY
BONE MARROW
BRAIN
CENTRAL NERVOUS SYSTEM
CLEARANCE
DATA
DATA FORMS
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DISTRIBUTION
DOSES
DOSIMETRY
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
EXPERIMENTAL DATA
FEMALE GENITALS
GLANDS
GONADS
HEMATOPOIETIC SYSTEM
INFORMATION
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOLATED VALUES
ISOTOPES
LIGHT NUCLEI
LIVER
MALE GENITALS
MAMMALS
MAN
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NITROGEN 13
NITROGEN ISOTOPES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
OVARIES
PRIMATES
RADIATION DOSES
RADIOISOTOPES
SINGLE INTAKE
TESTES
TISSUE DISTRIBUTION
TISSUES
URINARY TRACT
VERTEBRATES