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Effects of submicronic sulfuric acid aerosol on human pulmonary function

Journal Article · · Arch. Environ. Health; (United States)
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The effects of a 4-hr exposure in an environmental chamber to an average 108 ..mu..g/m/sup 3/ sulfuric acid (H/sub 2/SO/sub 4/ (MMAD, 0.5 ..mu..g)) on pulmonary function were examined in healthy young men. Subjects were randomly assigned to either experimental (N = 18) or control (N = 17) groups. All subjects were exposed to clean air on the first day. On the second day, experimental subjects were exposed to H/sub 2/SO/sub 4/ while control subjects were re-exposed to air. Subjects exercised for 15 min at 1.5 and 3.5 hr of exposure at an intensity equivalent to 75% of predicted maximal heart rate. Ventilation was monitored during the initial 14 min of each exposure. Pulmonary function was assessed prior to, and at 2 hr and 4 hr of each exposure. Exposure to H/sub 2/SO/sub 4/ had no significant effect on minute ventilation, respiratory frequency, or tidal volume, nor did it affect pulmonary function as assessed by measures of airway resistance, specific airway conductance, forced vital capacity (FVC), forced expiratory flow in 1 sec (FEV/sub 1.0/), FEV/sub 1.0//FVC, mean expiratory flow rate between 25% and 75% FVC, and expiratory flow rate at 50% and 25% FVC. It was concluded that no changes in pulmonary function resulted from exposure to H/sub 2/SO/sub 4/ under the above conditions.

Research Organization:
U.S. Environment Protection Agency, Research Triangle Park, NC
OSTI ID:
6721005
Journal Information:
Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 37:3; ISSN AEHLA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BODY
COLLOIDS
DISPERSIONS
FUNCTIONS
HYDROGEN COMPOUNDS
INHALATION
INORGANIC ACIDS
INTAKE
LUNGS
MALES
MAMMALS
MAN
MEN
ORGANS
PARTICLE SIZE
PATIENTS
PRIMATES
RESPIRATORY SYSTEM
SIZE
SOLS
SULFURIC ACID
VERTEBRATES