Pulmonary response to threshold levels of sulfur dioxide (1. 0 ppm) and ozone (0. 3 ppm)
The authors exposed 22 healthy adult nonsmoking male subjects for 2 h to filtered air, 1.0 ppm sulfur dioxide (SO/sub 2/), 0.3 ppm ozone (O/sub 3/), or the combination of 1.0 ppm SO/sub 2/ + 0.3 ppm O/sub 3/. They hypothesized that exposure to near-threshold concentrations of these pollutants would allow them to observe any interaction between the two pollutants that might have been masked by the more obvious response to the higher concentrations of O/sub 3/ used in previous studies. Each subject alternated 30-min treadmill exercise with 10-min rest periods for the 2 h. The average exercise ventilation measured during the last 5 min of exercise was 38 1/min (BTPS). Forced expiratory maneuvers were performed before exposure and 5 min after each of the three exercise periods. Maximum voluntary ventilation, He dilution functional residual capacity, thoracic gas volume, and airway resistance were measured before and after the exposure. After O/sub 3/ exposure alone, forced expiratory measurements (FVC, FEV1.0, and FEF25-75%) were significantly decreased. The combined exposure to SO/sub 2/ + O/sub 3/ produced similar but smaller decreases in these measures. There were small but significant differences between the O/sub 3/ and the O/sub 3/ + SO/sub 2/ exposure for FVC, FEV1.0, FEV2.0, FEV3.0, and FEF25-75% at the end of the 2-h exposure. The authors conclude that, with these pollutant concentrations, there is no additive or synergistic effect of the two pollutants on pulmonary function.
- Research Organization:
- Univ. of California, Santa Barbara
- OSTI ID:
- 5241397
- Journal Information:
- J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 6; ISSN JAPYA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Pulmonary function responses of young and older adults to mixtures of O sub 3 , NO sub 2 and PAN
Pulmonary function effects of 1. 0 and 2. 0 ppM sulfur dioxide exposure in active young male non-smokers
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
CHALCOGENIDES
DYNAMIC FUNCTION STUDIES
EXERCISE
MAXIMUM PERMISSIBLE EXPOSURE
OXIDES
OXYGEN COMPOUNDS
OZONE
RESPIRATION
SAFETY STANDARDS
STANDARDS
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
SYNERGISM