Pulmonary function effects of 1. 0 and 2. 0 ppM sulfur dioxide exposure in active young male non-smokers
The threshold concentration of sulfur dioxide which will induce pulmonary function changes in the normal population has not been established. To investigate this question, nine young healthy adult non-smoking males were exposed for 2 h to filtered air (FA), 1.0 ppM SO/sub 2/, and 2.0 ppM SO/sub 2/. In a follow-up study an additional 14 subjects were exposed to FA and 1.0 ppM SO/sub 2/ conditions. Forced expiratory tests were performed prior to and following the 2-h exposure, and 5 min after each of three 30-min exercise periods. The work load during the exercise periods was set to elicit a minute ventilation of 40 liters BTPS. Thoracic gas volume (TGV), airway resistance (Raw), maximal voluntary ventilation (MVV), and helium dilution functional residual capacity (FRC) were also measured before and after the exposure. In the initial subject group (n = 9), none of the spirometric tests demonstrated any significant effects to the subject from exposure to 1.0 or 2.0 ppM SO/sub 2/ either after 30 min of continuous exercise or 2 h of intermittent exercise. The only significant change (p < 0.05) was an increase in specific airway resistance (SRaw) following exposure to 1.0 or 2.0 ppM SO/sub 2/. However, when this observation was further studied in the larger (n = 23) subject group exposed to 1.0 ppM SO/sub 2/, neither SRaw nor any of the other pulmonary function tests indicated a significant effect of exposure to 1.0 ppM SO/sub 2/.
- Research Organization:
- Univ. of California, Santa Barbara
- OSTI ID:
- 5780390
- Journal Information:
- J. Air Pollut. Control Assoc.; (United States), Journal Name: J. Air Pollut. Control Assoc.; (United States) Vol. 34:11; ISSN JPCAA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Pulmonary response to threshold levels of sulfur dioxide (1. 0 ppm) and ozone (0. 3 ppm)
Inhalation route effects on exposure to 2. 0 parts per million sulfur dioxide in normal subjects
Related Subjects
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BODY
CHALCOGENIDES
CLEARANCE
EXCRETION
HAZARDS
HEALTH HAZARDS
LUNG CLEARANCE
LUNGS
MALES
MAMMALS
MAN
MEN
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
PRIMATES
RESPIRATORY SYSTEM
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
TOXICITY
VERTEBRATES