Brain edema and blood-brain barrier permeability following quantitative cerebral microembolism

Journal Article · Mon Jan 01 04:00:00 EST 1979 · Stroke; (United States)

DOI:https://doi.org/10.1161/01.STR.10.1.34· OSTI ID:6720563

Bralet, A M; Bdley, A; Beley, P; Bralet, J

Cerebral microemboli were formed in rats by injecting 4000 carbonized microspheres, 50 +- 10 mu in diameter, labelled with /sup 85/Sr, into the internal carotid artery. The use of radioactive microspheres as embolic agents enabled the number of microspheres to be determined in each cerebral hemisphere. The microspheres were mainly distributed in the cerebral hemisphere on the side of the injection. In 61 rats this hemisphere contained 582 +- 20 microspheres against 99 +- 9 in the contralateral hemisphere. Brain edema was assessed by measuring brain content of water, sodium and potassium. Blood-brain barrier (BBB) permeability was determined by brain accumulation of /sup 125/I-albumin. In the ipsilateral hemisphere brain edema and an increase in BBB permeability appeared 6 hours after embolization and progressed up to 48 hours. Twenty-four hours after embolization, significant correlations were observed between the microsphere content of the cerebral hemispheres and (1) increases in water and sodium levels, (2) the decrease in potassium level, (3) the increase in BBB permeability. The study of these correlations should make it possible to ignore the poor reproducibility of embolizations and to analyze with increased accuracy the results of various experiments.

• Research Organization: Faculty of Medicine and Pharmacy, Dijon, France
• OSTI ID: 6720563
• Journal Information: Stroke; (United States), Journal Name: Stroke; (United States) Vol. 10:1; ISSN SJCCA
• Country of Publication: United States
• Language: English

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551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
ALKALI METALS
ALKALINE EARTH ISOTOPES
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BLOOD VESSELS
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARDIOVASCULAR SYSTEM
CAROTID ARTERIES
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
EDEMA
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EMBOLI
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALS
MICROSPHERES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PERMEABILITY
POTASSIUM
PROTEINS
RADIOISOTOPES
RATS
RODENTS
SODIUM
STRONTIUM 85
STRONTIUM ISOTOPES
SYMPTOMS
TRACER TECHNIQUES
VERTEBRATES
WATER