Cerebral embolism: local CFBF and edema measured by CT scanning and Xe inhalation. [Baboons]

Journal Article · Tue Jan 01 04:00:00 EST 1980 · Neurol. Res.; (United States)

OSTI ID:5878254

Meyer, J S; Yamamoto, M; Hayman, L A; Sakai, F; Nakajima, S; Armstrong, D

Serial CT scans were made in baboons after cerebral embolization during stable Xe inhalation for measuring local values for CBF and lambda (brain-blood partition or solubility coefficients), followed by iodine infusion for detecting blood-brain barrier (BBB) damage. Persistent zones of zero flow surrounded by reduced flow were measured predominantly in subcortical regions, which showed gross and microscopic evidence of infarction at necropsy. Overlying cortex was relatively spared. Reduced lambda values attributed to edema appeared within 3 to 5 minutes and progressed up to 60 minutes. Damage to BBB with visible transvascular seepage of iodine began to appear 1 to 1 1/2 hours after embolism. In chronic animals, lambda values were persistently reduced in areas showing histologic infarction. Contralateral hemispheric CBF increased for the first 15 minutes after embolism, followed by progressive reduction after 30 minutes (diaschisis).

• OSTI ID: 5878254
• Journal Information: Neurol. Res.; (United States), Journal Name: Neurol. Res.; (United States) Vol. 2:2; ISSN NRESD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
APES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD-BRAIN BARRIER
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBROSPINAL FLUID
CEREBRUM
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
EDEMA
EMBOLI
EVEN-ODD NUCLEI
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
NERVOUS SYSTEM
NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SYMPTOMS
TOMOGRAPHY
VERTEBRATES
XENON 133
XENON ISOTOPES