Histopathology of hepatic acute graft-versus-host disease in the dog. [Gamma radiation]

Journal Article · Tue Aug 01 04:00:00 EDT 1978 · Transplantation; (United States)

OSTI ID:6716952

Sale, G E; Storb, R; Kolb, H

To test the association of small bile duct destructive lesions in the liver with acute graft-versus-host disease, a blind (coded) histological study was done comparing liver tissue from three groups of dogs given 1,200 R of total-body irradiation: one not given marrow infusions after irradiation, another given autologous hemopoietic grafts, and a third given marrow grafts from DLA-nonidentical unrelated donors. The dogs with unrelated grafts all developed graft-versus-host disease, and their liver histology was distinguished from that of the dogs in the other two groups of three findings: extensive small bile ductule necrosis and atypia; infiltrates of mononuclear cells around and in ductules; and individual hepatocyte necrosis scattered throughout the lobules. Thus, bile duct lesions appear to be a good marker for assessing the presence and severity of hepatic graft-versus-host disease in dogs.

• Research Organization: Fred Hutchinson Cancer Research Center, Seattle
• OSTI ID: 6716952
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 26:2; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BILIARY TRACT
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
DIGESTIVE SYSTEM
DISEASES
DOGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GLANDS
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
HISTOLOGY
IONIZING RADIATIONS
LIVER
MAMMALS
NECROSIS
ORGANS
PATHOLOGICAL CHANGES
PATHOLOGY
RADIATION EFFECTS
RADIATIONS
TISSUES
TRANSPLANTS
VERTEBRATES