Cyctotoxicities of mitomycin C and x rays to aerobic and hypoxic cells in vitro
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Aerobic and hypoxic EMT6 mouse mammary tumor cells in exponential growth in vitro were used to study cell survival after treatment with radiation (250k V X rays) and mitomycin C in various combinations. The cytotoxicities of the two agents were found to be additive as judged by comparing dose-response curves for each agent alone with survival curves after combination therapy and by isobologram analysis. The cytotoxicities resulting from combination treatments were found to be independent of the sequence of the treatments or the interval between treatments.
- OSTI ID:
- 6714938
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:6; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of mitomycin C alone and in combination with X-rays on EMT6 mouse mammary tumors in vivo
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Journal Article
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Sat Oct 01 00:00:00 EDT 1983
· J. Natl. Cancer Inst.; (United States)
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OSTI ID:6742990
Combination therapy with misonidazole and mitomycin C: lack of chemosensitization of EMT6 tumor cells in vivo or in vitro
Journal Article
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Sat Sep 01 00:00:00 EDT 1984
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
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Combination therapy with radiation and mitomycin C: preliminary results with EMT6 tumor cells in vitro and in vivo
Conference
·
Sat Sep 01 00:00:00 EDT 1979
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5340081
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
DRUGS
ELECTROMAGNETIC RADIATION
IN VITRO
IONIZING RADIATIONS
MAMMALS
MICE
MITOMYCIN
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SURVIVAL CURVES
SYNERGISM
TOXICITY
TUMOR CELLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
DRUGS
ELECTROMAGNETIC RADIATION
IN VITRO
IONIZING RADIATIONS
MAMMALS
MICE
MITOMYCIN
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SURVIVAL CURVES
SYNERGISM
TOXICITY
TUMOR CELLS
VERTEBRATES
X RADIATION