Comparison of cold pressor and exercise radionuclide angiocardiography in coronary artery disease
To investigate the role of the cold pressor test (CPT) with radionuclide angiocardiography in the diagnosis of coronary artery disease (CAD), we performed angiocardiography in 52 patients (18 with angiographically normal coronary arteries and 34 with CAD) during the resting state, CPT, and supine bicycle exercise (EX). In normal subjects, left ventricular ejection fraction (EF) was unchanged between rest (58 +/- 9%) and CPT (59 +/- 9%, p . ns), but increased during maximal EX (69 +/- 9%, p less than 0.01). In CAD patients, EF fell from 55 +/- 9% at rest to 49 +/- 9% during CPT (p less than 0.01), and to 53 +/- 11% during EX (p . ns vs. rest). Twenty-seven CAD patients (79%) developed new or worsening areas of dyssynergy during CPT, vs. 25 patients (73%) during EX. Thus, the cold pressor test with radiocardiography appears to be a useful noninvasive test for the diagnosis and functional evaluation of CAD, particularly in patients unable to perform a satisfactory exercise test.
- Research Organization:
- Baylor College of Medicine, Houston, Texas
- OSTI ID:
- 6711373
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 23:9
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
BLOOD VESSELS
BIOMEDICAL RADIOGRAPHY
CARDIOVASCULAR DISEASES
DIAGNOSIS
CORONARIES
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DYNAMIC FUNCTION STUDIES
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PATIENTS
RADIOISOTOPES
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CARDIOVASCULAR SYSTEM
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DISEASES
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NUCLEAR MEDICINE
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550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques