Insensitivity of the cold pressor stimulation test for the diagnosis of coronary artery disease

Journal Article · Wed Jun 01 04:00:00 EDT 1983 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.67.6.1189· OSTI ID:5299145

Wasserman, A G; Reiss, L; Katz, R J; Leiboff, R; Cleary, P; Varma, V M; Reba, R C; Ross, A M

Cold pressor stimulation (CPS) was compared with supine bicycle exercise during radionuclide ventriculography as a procedure for diagnosing coronary artery disease (CAD). Thirty patients were studied. In the 18 patients with angiographically proved CAD, left ventricular ejection fraction (LVEF) decreased a mean of 5.0 +/- 1.0 ejection fraction units (+/- SEM) in response to CPS. Only two patients developed a new wall motion abnormality. In response to maximal supine exercise, the CAD group showed a mean decrease in LVEF from rest of 1.9 +/- 1.1%. Nine patients developed an exercise-induced wall motion abnormality. In the 12 patients with angiographically proved normal coronary arteries, LVEF decreased a mean of 5.8 +/- 1.3 units in response to CPS and increased a mean of 9.2 +/- 1.2% in response to exercise. Thus, the LVEF response to CPS was not significantly different in the CAD and normal groups (5.0 +/- 1.0 vs 5.8 +/- 1.3, NS). These same patients demonstrated the expected difference in LVEF response to exercise. We conclude that CPS produces similar changes in LVEF in patients with and without CAD, and therefore is not useful in diagnosing ischemic heart disease.

• Research Organization: Division of Cardiology, George Washington University Medical Center, Washington, DC
• OSTI ID: 5299145
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 67:6; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BIOLOGICAL STRESS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
CORONARIES
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
EXERCISE
ISOTOPES
ORGANS
TECHNETIUM ISOTOPES
USES