Teletherapy for stage C adenocarcinoma of the prostate

Journal Article · Thu Jul 01 04:00:00 EDT 1982 · J. Urol.; (United States)

OSTI ID:6709764

Lupu, A N; Petrovich, Z; Corvalan, J; Katske, F A; Kaufman, J J

From 1967 to 1977, 22 patients with clinical stage C adenocarcinoma of the prostate received external beam radiation therapy with curative intent. The crude rate of survival was 100 per cent at 2 years and 64 per cent (14 of 22) at 5 years post-radiation. Metastatic disease developed in 14 patients (64 per cent) 1 to 5 years after radiation therapy, 5 of whom (23 per cent) died of the disease. Eight patients (36 per cent) who were followed 5 to 14 years after radiation therapy achieved a status free of disease. When results were analyzed according to grade 100 per cent of the patients with grade 1 (well differentiated) carcinoma survived free of disease 7 to 14 years post-radiation and 40 per cent with grade 2 (moderately differentiated) carcinoma survived free of disease 5 to 7 years. Of those patients with grade 3 (poorly differentiated) carcinoma none became free of disease and 63 per cent died of cancer 3 to 5 years after radiotherapy. Local control was achieved in 100 per cent of the patients with grade 1 tumors, in 70 per cent with grade 2 disease and in 50 per cent with grade 3 cancer. We conclude that the degree of tumor differentiation is a major determinant in the response of stage C adenocarcinoma of the prostate to external beam radiation therapy.

• Research Organization: Urology Section, Sepulveda Veterans Administration Hospital, California
• OSTI ID: 6709764
• Journal Information: J. Urol.; (United States), Journal Name: J. Urol.; (United States) Vol. 128:1; ISSN JOURA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DISEASES
EVALUATION
EXTERNAL IRRADIATION
GLANDS
IRRADIATION
MALE GENITALS
MEDICINE
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PROSTATE
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
THERAPY
TUMOR CELLS