Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Preliminary observations on the results of combined /sup 125/I seed implantation and external irradiation for carcinoma of the prostate

Journal Article · · J. Urol.; (United States)
OSTI ID:6779550
; ; ; ; ;

Fifty-seven patients with localized carcinoma of the prostate were treated with pelvic lymphadenectomy and a reduced /sup 125/I implant dosage, supplemented by a moderate dose of external beam radiotherapy to the whole pelvis delivered 4 to 6 weeks later. The incidence of pelvic nodal metastases was 28 per cent and the operative morbidity was 15 per cent. Late radiation sequelae developed in 18 patients, including 15 patients with radiation proctitis (29 per cent), among whom 2 (4.6 per cent) suffered rectal ulceration and required diverting colostomy. Followup has been 2 years or longer (median 33 months) in 26 patients, of whom 22 (85 per cent) are free of disease. Three patients are living with osseous metastases or local disease and there has been 1 death of prostatic carcinoma, for an absolute 2-year survival rate of 95 per cent. Of the 7 patients with poorly differentiated tumor and of the 8 patients with positive pelvic lymph nodes 5 and 6, respectively, remain free of disease after a minimum 2-year followup. Potency has been lost in 20 per cent and reduced significantly in 30 per cent of the patients followed 18 months or longer. Prostatic biopsies on 28 asymptomatic patients 12 to 30 months after completion of therapy showed no tumor in 21 (75 per cent).

Research Organization:
Department of Surgery, University of Missouri School of Medicine, Columbia
OSTI ID:
6779550
Journal Information:
J. Urol.; (United States), Journal Name: J. Urol.; (United States) Vol. 127:4; ISSN JOURA
Country of Publication:
United States
Language:
English

Similar Records

Prophylactic pelvic girdle irradiation in the treatment of prostatic carcinoma
Journal Article · Mon Jun 01 00:00:00 EDT 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:6341562
Radiation therapy in adenocarcinoma of the prostate with pelvic lymph node involvement on lymphadenectomy
Journal Article · Thu Jan 31 23:00:00 EST 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:6866050
SVI implantation for carcinoma of the prostate: 5-year survival free of disease and incidence of local failure
Journal Article · Sat Nov 30 23:00:00 EST 1985 · J. Urol.; (United States) · OSTI ID:6294735

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
EXTERNAL IRRADIATION
GASTROINTESTINAL TRACT
GLANDS
IMPLANTS
INTERNAL IRRADIATION
INTESTINES
IRRADIATION
LARGE INTESTINE
LOCAL IRRADIATION
MALE GENITALS
MEDICINE
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PELVIS
PROCTITIS
PROSTATE
RADIATION EFFECTS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RECTUM
SIDE EFFECTS
THERAPY