Combined gold seed implantation and external radiotherapy for stage B2 or C prostate cancer

Journal Article · Sun May 01 04:00:00 EDT 1988 · J. Urol.; (United States)

OSTI ID:6969444

Carey, P O; Lippert, M C; Constable, W C; Jones, D; Talton, B M

Patients with clinical stage B2 or C prostatic carcinoma represent a group for which there are several treatment options. We followed the course and outcome of 72 patients with clinical stages B and C prostate cancer who were treated with surgical staging, insertion of gold grains and external radiation at our institutions between 1975 and 1984. Of the patients 44 (61 per cent) had clinical stage B disease and the majority (89 per cent) of these were stage B2 lesions. The remaining 28 patients (39 per cent) had clinical stage C tumors. In our series 27 per cent of the clinical stage B and 68 per cent of the clinical stage C cancer patients had positive lymph nodes. The 5-year survival free of disease was 52 per cent for patients with both stages of disease. The 7-year survival free of disease was 47 per cent for patients with clinical stage B and 14 per cent for those with clinical stage C cancer. Lymph node status did not have a statistically significant effect on total survival but survival free of disease correlated significantly with node status. Local treatment failures were defined as patients who required transurethral prostatic resection or orchiectomy for palliation of obstructive symptoms related to local tumor regrowth. By these criteria we prevented local progression in 78 per cent of the patients at 5 years.

• Research Organization: Univ. of Virginia Medical School, Charlottesville (USA)
• OSTI ID: 6969444
• Journal Information: J. Urol.; (United States), Journal Name: J. Urol.; (United States) Vol. 139:5; ISSN JOURA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
CARCINOMAS
DISEASES
ELEMENTS
GLANDS
GOLD
IMPLANTS
LYMPH NODES
LYMPHATIC SYSTEM
MALE GENITALS
MEDICINE
METALS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PROSTATE
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOLOGY
RADIOTHERAPY
SURVIVAL CURVES
THERAPY
TRANSITION ELEMENTS