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Brachytherapy with Cf-252 in USSR: Head and neck, GYN and other tumors

Journal Article · · Nucl. Sci. Appl.; (United States)
OSTI ID:6708507
;
The USSR program in /sup 252/Cf neutron brachytherapy has been conducted in 5 centers which have conducted clinical trials on --721 patients through early 1985. The majority of patients had head and neck tumors (61%), uterine cervix and uterus (27%) and other sites (skin, soft tissues, etc. - 12%). In 83% the histology was squamous cell carcinoma, 14% adenocarcinoma and 3% melanoma, sarcoma, etc. More rapid tumor clearance followed /sup 252/Cf treatment than after /sup 60/Co irradiation for head and neck, and cervix cancers and no resistant histological types were found. Complete regression of recurrent tumors was observed in 81/93 (87%) of patients treated. In 142 head and neck tumors of the tongue, floor of mouth and oropharynx, early vs. delayed /sup 252/Cf implants were compared against conventional /sup 60/Co therapy. Delayed neutron therapy was somewhat worse than conventional photon therapy. For T2 tongue carcinoma, complete regression was obtained in 96% and 2 year survival in 92% with early implants vs. 53% for delayed neutron therapy and 75% for /sup 60/Co. For T2 floor of mouth cancer complete regression was obtained in 100% and 2 year survivals were 86% for early /sup 252/Cf implants vs. 46% for delayed /sup 252/Cf and 66% for conventional therapy. For 65 advanced cervix cancers treated with delayed /sup 252/Cf therapy 62% survived 2-5 years and 60 control patients treated with conventional radiation 55% survived 2-5 years. For patients with corpus adenocarcinomas the survival in 37 patients was 94% vs. 73% in 30 control patients. Complication rates in each site were of the same degree and severity as with photon radiotherapy.
Research Organization:
Research Institute of Medical Radiology of Academy of Medical Science of U.S.S.R., Obninsk
OSTI ID:
6708507
Journal Information:
Nucl. Sci. Appl.; (United States), Journal Name: Nucl. Sci. Appl.; (United States) Vol. 2:3; ISSN NSAPD
Country of Publication:
United States
Language:
English

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Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ASIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CLEARANCE
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DISEASES
EASTERN EUROPE
ELEMENTARY PARTICLES
EUROPE
EVEN-EVEN NUCLEI
FEMALE GENITALS
HEAD
HEAVY NUCLEI
IMPLANTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MASSLESS PARTICLES
MEDICAL ESTABLISHMENTS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NECK
NEOPLASMS
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATIENTS
PHOTONS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RESEARCH PROGRAMS
THERAPEUTIC USES
THERAPY
USES
USSR
UTERUS
YEARS LIVING RADIOISOTOPES