Clinical trial of /sup 252/Cf neutron brachytherapy vs. conventional radiotherapy for advanced cervical cancer

Journal Article · Thu Aug 01 00:00:00 EDT 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90335-9· OSTI ID:5228638

Maruyama, Y; Kryscio, R; Van Nagell, J R; Yoneda, J; Donaldson, E; Hanson, M; Beach, J L; Feola, J M; Martin, A; Parker, C

/sup 252/Cf, a neutron emitting radioactive transplutonium isotope, was tested for its efficacy against advanced bulky Stage III-IV cancers of the cervix in a clinical trial at the University of Kentucky Medical Center. Eighty-two patients were treated during 1976-1979 and followed for 5-year survival and tumor control. Three different treatment methods went on sequentially and concurrently, that is, (a) conventional whole pelvis photon with delayed /sup 137/Cs implants, (b) conventional photon therapy with delayed /sup 252/Cf implants, and (c) /sup 252/Cf implants (early) preceding photon therapy. For early /sup 252/Cf implant therapy there were 54% 5-year survivals with 4% complications and 65% 5-year local control, but distant metastases became a prominent delayed failure pattern.

• Research Organization: Univ. of Kentucky Medical Center, Lexington
• OSTI ID: 5228638
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:8; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
AFTERLOADING
ALKALI METAL ISOTOPES
ALPHA DECAY RADIOISOTOPES
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CESIUM 137
CESIUM ISOTOPES
COMPARATIVE EVALUATIONS
DELAYED RADIATION EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EVEN-EVEN NUCLEI
FEMALE GENITALS
FERMIONS
FISSION NEUTRONS
GAMMA RADIATION
HADRONS
HEAVY NUCLEI
IMPLANTS
IONIZING RADIATIONS
ISOTOPES
MEDICINE
NEOPLASMS
NEUTRON THERAPY
NEUTRONS
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY
UROGENITAL SYSTEM DISEASES
UTERUS
YEARS LIVING RADIOISOTOPES